PostHeaderIcon Mandelic Acid Information

Wikipedia defines Mandelic Acid as, “an aromatic alpha hydroxy acid with the molecular formula C8H8O3. It is a white crystalline solid that is soluble in water and most common organic solvents”.  The product was apparently discovered whilst heating an extract of bitter almonds, and the name is derived from the German word, “Mandel”, for “almond”.

Mandelic Acid Molecule

According to Wikipedia, Mandelic Acid has gained popularity as a “topical skin care treatment for adult acne”.  Mandelic acid also has the benefit over glycolic acid, of having unique, antibacterial properties.

Mandelic Acid is considered appropriate treatment for not only acne, but also wrinkles, and pre- and post-laser treatment, “reducing the amount and length of irritation caused by laser resurfacing”.

Mandelic acid is known chemically as alpha-hydroxybenzeneacetic acid, and is a larger molecule than Glycolic acid (the most well-known alpha hydroxy acid), making mandelic acid more tolerated on the skin.  Mandelic acid also belongs to a group of alpha hydrolic acids known as aromatic alpha hydroxy acids, and is in fact, the smallest aromatic alpha hydroxy acid.

According to Mandelic,

Mandelic acid has long been used in the medical community as an antibacterial, particularly in the treatment of urinary tract infections, as well as an oral antibiotic. Lately, Mandelic acid has been receiving greater attention as a topical skin care treatment. Dermatologists now suggest Mandelic acid as an appropriate treatment for a wide variety of skin concerns, from acne to wrinkles; it is especially good in the treatment of adult acne as it addresses both of these concerns. Mandelic acid is also recommended is a pre- and post-laser treatment, reducing the amount and length of irritation caused by laser resurfacing.

Commercially, mandelic acid can be found in products such as cleansers, face washes, moisturizers, eye-lift creams, and more. Some of the best mandelic acid products are from Nucelle Skincare. Nucelle has a side range of skincare products to treat a wide variety of skin conditions. Visit for more info

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PostHeaderIcon Great articles on Mandelic Acid for Acne Treatment !

Here are some great articles which include Mandelic Acid as a great treatment for acne !—3-Step-Guide&id=5719594

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PostHeaderIcon Mandelic Acid for Acne, Adult Acne, and Pimples

Suffering from acne and pimples as a teenager is considered to be quite normal, and if you were one of those teens who did not break out during your pubescent years, you must be extremely lucky!  We can all remember those unsightly blackheads, acne, whiteheads and the guaranteed pimple whenever there was important event or worse – date with a boy!

As we age , we expect that we will discontinue suffering from these public displays of embarrassment, however, many adults, especially women, experience acne throughout their adult years.

As adults though, our skin does not tend to be as resilient as it was when we were younger.  Do you remember being told as a teen not to pick your pimples, as they are likely to scar?  The unfortunate news is that, as adults, whether we pick our acne or not, they are more likely to leave behind marks, and further excentuate the appearance of our aging skin.

If you are an adult who is suffering from acne, you are likely to be seeking a product that will not only reduce, if not eliminate, your acne; but also reduce the signs of aging on your skin.

The great news is that Mandelic acid is an ingredient that has been proven to cater for both of these needs – improving the texture of your skin and restoring it back to its natural, youthful state.

Mandelic Acid is a member of the alpha hydroxy acid family, such as the well-known skin care treatment glycolic acid.  Mandelic acid is a substance that is derived from the bitter almond, and although most alpha hydroxy acids tend to be harsh on the skin, and particularly irritable to sensitive skin types, with the ability to leave the skin feeling red and raw, Mandelic Acid is in a different category.
Mandelic Acid is a larger molecule than most other alpha hydroxy acids, which means that it takes longer to penetrate our mulitple layers of skin – this allows for a more even treatment of the skin.
In comparison, other alpha hydroxy acids are smaller molecules, which means they are often absorbed more rapidly, often causing redness and irritation.
Mandelic acid has proven to be more gentle on the skin in this respect, and is particularly of benefit to people who have a sensitive skin type, including sufferers of skin rosacea.
Why is Mandelic Acid suitable for treating adult acne and pimples ?  Because mandelic acid has unique anti-bacterial properties that are not common to other alpha hydroxy acids.  Pimples, black heads and postules are more often caused by bacteria in clogged pores.  One of the main benefits of alpha hydroxy acids is the exfoliation of the skin, assisting in the removal of dull surface layer skin, dead skin cells and debris, as well as other common pollutants such as bacteria, dirt and oils – which often clog up our pores and cause acne to develop.  Mandelic acid, however, does all of this without the side effects of common AHA’s, such as skin irritation.
NuCelle Inc offers a full skincare range that effectively deals with adult acne and pimples, with its active ingredient being mandelic acid.  NuCelle’s mandelic acid skincare formulations are known for not only their reducing, if not eliminating, pimples and adult acne, however their skincare range are growing in populatiry for an effective anti-aging treatment, thus making their products ideal for all-round treatment of adult skin.  NuCelle’s mandelic acid skincare formulations also offer beneficial vitamins and antioxidants with the aim to create optimum healing for all skin types, the outcome being revitalized, youthful skin.

Initially, mandelic acid was used in the treatment of raw and exposed skin that occurs after laser treatments. Due to its delicate and gentle nature, mandelic acid offers superior healing properties that effectively sooths irritable skin.  The use of mandelic acid in the treatment of common skin complaints have resulted in longer term effects of smoother, more youthful skin, assisting with skin antiaging, improving the appearance of fine lines and wrinkles, and providing a less irritating solution to these issues than other AHAs.
Today, mandelic acid is used widely for not only acne, adult acne, and pimples, but also other common skin issues such as rosacea, hyperpigmentation skin, melasma, anti-aging, fine-lines and wrinkles, and other skin complaints. NuCelle‘s customers have seen improvements to their skin that have lasted for years, gradually reducing the appearance of scars, lines, hyperpigmentation and discolouration of the skin; thus winning its popularity as one of the top skincare products on the market for all-round skincare issues and anti-ageing.
If you feel you have exhausted your options with your acne, adult acne, and pimples, but have not yet experienced mandelic acid’s proven effects, we recommend that you try NuCelle’s Mandelic Acid Skincare Formulations.

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PostHeaderIcon Mandelic Acid for Rosacea

Rosacea is a fairly common skin disease, which more frequently affects people with fair skin, such as those with Irish, Scottish and Northern European backgrounds.  This explains why you will sometimes hear people refer to Rosacea as the “curse of the Celts”.

Women have more of a tendency of suffering from Rosacea than men (in the primary stages, the ratio of women to men suffering from skin rosacea is 3:1).  However, men are more likely to experience swelling tissue, which leads to rhinophyma (depicted by an enlarged, bumpy nose).

Clinical studies have shown that exposure to the sun and heat can significantly affect Rosacea, and therefore it is of utmost importance to protect the skin from the sun whilst suffering from and treating Rosacea.  NuCèlle recommends the use of a protective, broad spectrum SPF 30+ sunscreen that is suitable for sensitive skin types, such as SunSense™ SPF 30+ Sunscreen.

Skin rosacea appears as a dark redness across the centre of the face, somewhat like permanent sunburn
Rosacea appears as a dark redness across the centre of the face, somewhat like permanent sunburn

Although genetics, gastrointestinal disturbances, and bacteria are all shown to be contributing factors towards the development of Rosacea, skin specialists are confident that the sun’s role should not be underestimated in the cause behind skin rosacea.  People who are inclined to blush, are also viewed as being particularly susceptible to developing rosacea.

Rosacea develops in stages, usually beginning with constant blushing, and eventually developing into an abnormal dark redness around the nose and cheek area.  Rosacea tends to occurs in individuals within the age range of 20-40 years, and there is a trend of rosacea peaking between the ages of 40 and 50 years.  After many years, especially in severe cases, Rosacea can develop into swelling and redness (hypertrophy), which most commonly occurs on the sufferer’s nose (known as rhinophyma).

Although Rosacea is most commonly experienced on the central areas of the face (the cheeks and nose), it can sometimes occur in the neck area and upper region of the chest.  It is believed that people who frequently blush, whether from reacting to stimulants such as strong emotions, alcohol, heat and/or cold or spicy foods, are most likely to develop a more permanent redness on the face and/or neck, over longer term (the early stages of Rosacea).

Recommended Rosacea Skincare Products

Below is a list of recommended Rosacea Skincare products containing Mandelic Acid. It’s important to maintain a daily skincare regimen when dealing with Rosacea. We’ve made it easy here, by recommending the top Mandelic Acid products which will yield the most satisfying results on your road to clearing Rosacea. Mandelic Acid is one of the most gentle skincare products, which is ideal for Rosacea sufferers’ sensitive skin. Mandelic Acid is also great for reducing redness by reducing inflammation and irritation.

1) Cleanser

Nucelle Mandelic Wash

You’re going to need a gentle, yet effective cleanser which will lightly clear your skin while avoiding irritation. Nucelle Mandelic Wash is a great cleanser, which contains 0.5% Mandelic Acid which will leave your skin smooth and reduce post washing flushes. For more info and to purchase visit:

Retail Price:
2 oz. – US$10.00
4 oz. – US$17.00
8 oz. – US$28.00

2) Moisturizer

Nucelle Anti-Oxidant Moisturizer

An absolute must for Rosacea is a great Moisturizer. We suggest anAntioxidant Moisturizer because it has essential, non-irritating vitamins which other moisturizers lack. Nucelle for example has a regular moisture shine control moisturizer which would be good for oily-acne skin, but wouldn’t be the ideal moisturizer for Rosacea. It contains 2% Mandelic acid which is ideal for containing the redness. Mandelic acid is unique because of its molecular size; it’s not as easily absorbed by your skin which makes it perfect for Rosacea sufferers. Easily absorbed skincare products such as salicylic acid products tend to irritate the skin. For more info and to purchase visit:

Retail Price:
2 oz. – US$30.00
8 oz. – US$77.00

3) Moisturizing Masque

Nucelle Mandelic Moisturizing Masque

Moisturizing is so important for treating Rosacea. The trick though is to exfoliate and moisturize with using the least amount of products in order to avoid irritation. Moisturizing Masques are a gentle way to do both. After it exfoliates, it leaves behind a moisturized finish. Flushes can sometimes be triggered from washing, so use cool-warm water and don’t rub too hard, a good Moisturizing Masque for rosacea will come off easily, with minimal rubbing. For more info and to purchase visit:

Regular Retail Price US$30.00

4) Sunscreen

Nucelle SPF-30 Sunscreen

While treating Rosacea, it is crucial to protect the skin from heat and sun exposure, and just as important to locate a sunscreen that does not irritate or inflame the skin, such as NuCèlle’s SunSense™ SPF 30+ Sunscreen. Sunscreen is so important because Rosacea can be made much worse from excessive sun exposure. The sun is harmful for Rosacea sufferers because it enlarges and damages the capillaries and blood vessels in the face, which therefore affects flushing. For more info and to purchase visit:

Retail Price:
2 oz. – US$10.00
4 oz. – US$17.00
8 oz. – US$28.00

Topical treatments for Rosacea include:

  • Topical Antibiotics – used to treat acne, may offer an effective solution. NuCèlle’s
    Mandelic Marine Complex®
    contains Mandelic Acid with natural antibacterial properties.
    A dermatologist can also recommend prescription antibiotics.
  • Retinoids – such as the Tretinoin products Retin-A and Renova, offer another alternative.
  • Azelaic Acid – which has anti-inflammatory properties
  • Salicylic Acid and Mandelic Acid – two of the mildest exfoliants available, and therefore are able to
    accommodate the sensitive skin of rosacea patients.  Exfoliation plays a fundamental role in eliminating the papules and postules of rosacea.
  • Vitamin C (L- Ascorbic acid) – proven to be especially effective in reducing the redness of rosacea. Begin with a milder concentration and make sure to perform a pretest in an inconspicuous area, as Vitamin C products, such as L-Ascorbic acid, may be irritating to some patients.
  • Sunscreeens - select products with titanium dioxide or zinc oxide to ensure a gentle formula for sensitive skin.  Choose a broadspectrum sunscreen with UVA,UVB and infrared protection, with an SPF (sunprotection factor) of at least 15, preferably 30+
Protection from the sun is of utmost importance when treating skin rosacea

For more information, and to view photographs of a Rosacea sufferer before the treatment of NuCèlle’s mandelic acid skincare system, and after six weeks of using the NuCèlle mandelic acid skincare formulations - click here – the results are stunning!

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PostHeaderIcon Mandelic Acid for Wrinkles, Fine-Lines and Anti-aging

Being an alpha hydroxy acid, mandelic acid is an ideal treatment for skin antiaging, to help diminish and prevent the signs of aging, such as worry lines, skin damage and wrinkles.  The way alpha hydroxy acids work, is that they accelerate the natural turnover rate of skin cells, effectively removing dead skin cells, debris and other skin pollutants that dull the complexion and accentuate the natural creases in the skin – making us appear more aged.  Mandelic acid is wonderful, as it also addresses the break down of collagen – the other main cause of wrinkles.  Collagen is an essential fiber in our skin, that replenishes itself easily when the skin is young.  However, as our skin ages, collagen production slows and the fibers weaken, leading to wrinkle formation.  Mandelic acid helps to strengthen the collagen in our skin, thus delaying and in some cases reversing the signs of aging, reducing the appearance of wrinkles in the skin.

A clinical trial conducted at the Gateway Aesthetic Institute and Laser Center in Salt Lake City, treated 1100 patients with NuCelle Mandelic Marine Complex formulations over a period of three years. The results of this trial showed dramatic changes in skin condition within weeks into the treatment program.  An excerpt from the report from these clinical trials, “Summary of Mandelic Acid for the Improvement of Skin Conditions“, in regards to skin antiaging, is highlighted below:

“Fine wrinkes and lines appear to improve, much like photoaged skin does with the use of 10% glycolic acid preparations.  Skin texture improves quickly within days or weeks in characteristic AHA therapeutic fashion.  A  notable difference between glycolic acid and mandelic acid products is the lack of skin irritation and erythema that often accompanies skin treatments with glycolic acid  in 30% to 70% preparations  used for peeling.  As with glycolic acid, the effect is sustained over months and years of treatment, with gradual and continued improvement in fine lines and wrinkles being the characteristic benefit. 

It is noteworthy that a remarkable difference  was seen in the treatment of darkly pigmented skin types.  Improvement can be seen in fine wrinkles and lines in patients with Fitzpatrick skin types I through IV without any postinflammatory hyperpigmentation.  This includes Asian skin types, which have universally been able to use mandelic acid products without any postinflammatory hyperpigmentation.

In contrast, the author has observed in his dermatology practice  a large number of darkly pigmented patients who have developed irritation, erythema, and subsequent postinflammatory hyperpigmentation while treating the skin with 5% to 10% glycolic acid, tretinoin, or hydroquinone.”

It has been concluded that mandelic acid is a very gentle treatment for not only skin antiaging, but also skin rosacea, melasma / hyperpigmentation skin, face pimples and other common skin complaints.  Suitable for all skin types, including darker pigmented and Asian skins, mandelic acid has the benefit of antibacterial properties that glycolic acid lacks.  Thus, mandelic acid is a more superior alpha hydroxy acid, less likely to cause irritation to even the most sensitive skin types.

For more information on the above study, conducted by Dr. Mark B. Taylor, click here to read “Summary of Mandelic Acid for the Improvement of skin Conditions”. This informative report includes before and after photographs, showing the dramatic results of mandelic acid treatments on patients after as little as one month.

To commence your own skin antiaging treatment and start seeing your own results, visit NuCelle Inc.

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PostHeaderIcon Mandelic Acid For Melasma and Hyperpigmentation Skin

Melasma is a fairly common condition, particularly in women of child-bearing age, with up to 10% of cases occurring in males.  Melasma is essentially an acquired increase of pigmentation (hyperpigmentation skin), occurring in sun exposed areas of the body – most commonly on the face. Brownish in color, melasma is said to be exacerbated by sun exposure, pregnancy, oral contraceptives, and certain anti-epilepsy drugs.  Melasma is a skin condition that does not discriminate by race, however, there does tend to be a prominence of its occurrence among people with Latino and/or Asian backgrounds.

Due to the influence of the sun on melasma, it is more prevalent during the sunnier months of the year – summer and spring; and less obvious during the winter months, when there is generally a lower level of sun exposure.  The most common areas of the face that are affected by melasma are the cheeks, forehead, upper lip, nose, and chin (ie, the parts of the face that receive the most concentrated sun exposure).  Melasma is also known to occur on the forearms and shoulders, although this is less common.

Also known as pregnancy mask or chloasma, Melasma’s main cause has been long believed to be from fluctuating hormones (in particular, estrogen), with the majority of sufferers of melasma being pregnant women, or women on contraceptives.  However, results from studies have shown that hormones / estrogen cannot be held 100% responsible – since melasma can effect women of varying ages (as well as men).  Sun exposure would therefore appear to be a more common factor in the cause of melasma.

Epidermal melasma occurs in the epidermis, where skin pigment is produced.  This is considered a normal case of melasma.  However, sometimes this type of melasma can turn into dermal melasma.  This normally occurs if skin has become inflamed and excessively irritated, causing a temporary split between the dermis and epidermis, which can allow some hyperpigmented cells to drop from the epidermis to the dermis.  Once hyperpigmented cells have entered the dermis, it can be very difficult to treat the melasma, as the cells become resistant to topical treatments.  It is therefore very important to treat melasma very gently, to avoid excess irritation, so as to avoid the epidermal melasma developing into dermal melasma.

Treatment for Melasma and Hyperpigmentation Skin

Mandelic acid, when used as a treatment for melasma, has proven to be very effective, particularly in reducing the appearance of dermal melasma – considered the toughest form of melasma to treat due to its resistance to topical treatments.  The majority of cases of melasma contain both epidermal melasma as well as some dermal melasma.  Mandelic acid has been known to help break up the areas of hyperpigmentation skin to expose a more uniform complexion.  A previous clinical study has shown fantastic results of using mandelic acid for Melasma, whereby the skin condition was reduced by up to 50 percent in a short four week period, when a product containing Mandelic acid was used.

Although hydroquinone and steroids have been used to treat melasma, mandelic acid is considered to be a great alternative to these treatments of hyperpigmentation skin such as melasma as it does not offer the side effects found with hydroquinone and steroids.  Mandelic acid is also ideal for sensitive skin types or people whose skin hyperpigments easily.  However, the combination of mandelic acid and hydroquinone (or other bleaching formula) has had the most successful results in eliminating and reducing the appearance of melasma.

Licquorice and Vitamin C have also had some positive results when used in combination with other melasma and hyperpigmentation skin treatments, such as mandelic acid; however you may not notice any change when used as stand alone treatments.

Click here to read more about clinical studies using different treatments for melasma and hyperpigmentation skin.

Please note that it has been advised that without the daily use of sunscreen and other sun protection, treatments for melasma and hyperpigmentation skin will fail. When using sunscreen, be sure to select a sunscreen that is opaque and broad-spectrum, with an SPF of at least 30.  NuCelle Inc. recommends the use of SunSense™ SPF 30+ Sunscreen, stating that it is:

“a cosmetically elegant, oil-free sunscreen that incorporates two new patented technologies. Sun Caps® (encapsulated octyl-methoxycinnamate) technology allows us to use two-thirds less sunscreen chemicals and still obtain an SPF 30+ rating, which means fewer chemicals and less chance of irritation for sensitive skin. The Z-Cote HP1® (micro-fine zinc oxide), a substance made with nanotechnology, is the very highest quality zinc compound available so no white residue forms on the skin. The nanotechnology in Z-Cote produces a high-purity nanocrystalline zinc oxide, which allows the sunscreen to go on clear. Besides, the inorganic Z-COTE cannot be absorbed by the skin and will not cause allergic reactions.”


Get started on gently reducing the appearance of your melasma and hyperpigmentation skin now with mandelic acid, by selecting your skin type below:

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PostHeaderIcon Mandelic Acid for Acne and Pimples

Acne and pimples are one of the most common dermatological problems, with approximately 80% of Western adolescents suffering from acne, and approximately 95% of the population suffering from acne at some point during their lifetime.  If left untreated, acne can be the source of significant physical sequelae and psychological problems.  Acne is not considered just a problem of youth, as it often persists into middle age for some sufferers.

Use Mandelic Acid to Clear Face Pimples

If acne are treated early, scarring is more likely to be minimised, and it is therefore important to be proactive when dealing with acne.

Mandelic acid can, and is, used to help clear acne, including cystic acne, and also to regulate sebum production and help prevent repeat outbreaks of acne.  Due to its antibacterial properties,  Mandelic acid products are especially beneficial for adults, as they double up as skin anti-aging and anti wrinkle treatments, as well as helping to eliminate acne.

There are several mandelic acid products on the market, and NuCèlle Inc. are the only known mandelic acid-based skincare company who offer a full range of mandelic acid skincare products – from cleanser, toner and moisturizer, to mandelic acid-based spa products (masques and scrubs), mandelic acid serum (the essential base product for face pimples, melasma, rosacea, hyperpigmentation, anti ageing and wrinkles, and other common skin ailments), mandelic acid sun creams, anti-wrinkle eye creams and more.  For their full range of mandelic acid products, visit NuCèlle Inc.

If you search the internet for reviews on NuCèlle, you will encounter many success stories from people of all ages and races using NuCèlle’s mandelic acid skincare formulations for acne and other types of blemishes.  One of the best stories are from a woman who calls herself “Vivi”, and claims that NuCelle has saved her life!

Mandelic Acid Skincare Will Clear Your Face Pimples

Recommended Skincare Products for Acne

1) Cleanser/Facewash

Nucelle Mandelic Wash/Cleanser

A cleanser/facewash is arguably the best product in your regimen for acne treatment. The issue though is using the right one, and one that works. Typically store bought cleansers tend to contain Salicylic acid which is far less effective at treating acne than Mandelic acid. Mandelic Acid cleansers work by clearing the skin of dead skin cells and removing unnecessary oils. It’s not necessary to cleanse the skin excessively and anymore than twice a day, preferably once per day is acceptable.

Retail Price:
2 oz. – US$10.00
4 oz. – US$17.00
8 oz. – US$28.00

2) Toner

Nucelle Mandelic Acid Toner

Toners are applied typically after cleansing and help by minimizing the appearance of wrinkles. Toners also have some cleansing and moisturizing properties to help retain moisture in the skin after cleansing and to neutralize the pH of the skin.

Retail Price:
2 oz. – US$10.00
4 oz. – US$17.00
8 oz. – US$28.00

3) 10% /  15% Serum

Nucelle Mandelic Acid 10% Serum
The Serum is definitely among the top of the list for an acne-free skincare regimen.  Mandelic Acid Serums range from 10% to 15% and are available commercially. 30% serums may be sold, but under the supervision of Doctors due to its strength. 10% Serums are ideal for most acne sufferers such as mild-moderate level acne , whereas 15% is ideal for oilier and more severe cases of acne. The Serums are applied typically on dry skin and should be left on the skin for 15-30min. Then the Serum is washed off and followed by a moisturizer.
Retail Price:
2 oz. – US$30.00
4 oz. – US$50.00
8 oz. – US$80.00
4) Moisturizer
Nucelle Moisture Shine Control

A moisturizer is super important when dealing with acne, and most people are misled into thinking that acne skin should be dry and without oil in order solve acne…but this couldn’t be further from the truth. Actually dry skin can make acne worse because it overcompensates and produces more bad oil in order to counteract excessive cleansing.

Retail Price:
2 oz. – US$30.00
8 oz. – US$77.00

For more effective results, NuCèlle also recommends that you use an exfoliator to speed up the process of eliminating debris and old skin cells from the skin.  NuCèlle’s Papaya Skin Exfoliator is outstanding, and you will notice the difference to your skin from just one application.

FDA guidelines highly recommend the daily use of sun protection when applying any AHA to the skin.  NuCelle therefore created their own oil-free sunscreen lotions that not only protect your face from the damaging rays of the sun, however the products also have two thirds reduced sunscreen chemicals than regular sunscreens on the market.  This means less chance of irritation to the skin.

Below is a video instruction of NuCèlle’s four-step regime for beautiful, youthful skin.

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PostHeaderIcon NuCèlle Mandelic Acid Skincare Régime

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